Microsoft’s Malicious Software Removal Tool (MSRT) cleaned over 260,000 computers that were infected by Alureon (aka TDL3 or TDSS). See http://blogs.technet.com/mmpc/archive/2010/04/30/msrt-april-threat-reports-alureon.aspx for more details.
MSRT is effective against TDL3 up to version 2.273, but it has no effect against newer versions of TDL3 (spreading since April 2010). Hopefully Microsoft will be able to clean these soon. But the good news is that at least these 260,000 people were rescued.